Table 4 Allelic odds ratios and 95% confidence intervals for comparison of NOD1/CARD4 variants with IBD status in New Zealand IBD patients and Caucasians
Allelic odds ratios and 95% confidence intervals for comparison of NOD1 rs2075818 | Allelic odds ratios and 95% confidence intervals for comparison of NOD1 rs2075822 | Allelic odds ratios and 95% confidence intervals for comparison of NOD1 rs2907748 | ||||
|---|---|---|---|---|---|---|
CD | UC | CD | UC | CD | UC | |
OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
Female | 0.66 (0.46–0.96) | 0.94 (0.65–1.36) | 1.14 (0.79–1.64) | 1.18 (0.81–1.71) | 0.94 (0.66–1.34) | 0.87 (0.60–1.25) |
Male | 0.66 (0.42–1.04) | 1.02 (0.68–1.54) | 1.03 (0.66–1.61) | 1.33 (0.86–2.05) | 0.71 (0.46–1.09) | 0.76 (0.51–1.13) |
Age at first diagnosis | ||||||
0–16 years | 0.62 (0.33–1.15) | 0.94 (0.48–1.83) | 0.75 (0.44–1.28) | 1.11 (0.56–2.20) | 1.11 (0.65–1.90) | 1.20 (0.65–2.23) |
17–40 years | 0.67 (0.48–0.94) | 0.91 (0.66–1.26) | 1.03 (0.75–1.42) | 1.17 (0.84–1.64) | 0.88 (0.64–1.20) | 0.83 (0.60–1.14) |
>40 years | 0.66 (0.46–0.95) | 1.06 (0.77–1.45) | 1.36 (0.94–1.96) | 1.36 (0.97–1.91) | 0.72 (0.51–1.02) | 0.78 (0.57–1.07) |
CD location | ||||||
Ileal | 0.82 (0.56–1.19) | 1.15 (0.79–1.67) | 0.71 (0.49–1.03) | |||
Colonic | 0.59 (0.41–0.85) | 1.22 (0.86–1.72) | 0.80 (0.57–1.11) | |||
Ileocolonic | 0.60 (0.38–0.94) | 0.89 (0.60–1.33) | 1.03 (0.69–1.53) | |||
UC location | ||||||
Proctitis | 0.94 (0.67–1.32) | 1.05 (0.74–1.49) | 1.04 (0.75–1.44) | |||
Left colon | 1.14 (0.79–1.65) | 1.43 (0.95–2.16) | 0.85 (0.58–1.24) | |||
Pancolitis | 0.92 (0.65–1.31) | 1.40 (0.96–2.03) | 0.58 (0.40–0.84) | |||
CD Behavior | ||||||
Inflammatory | 0.59 (0.42–0.82) | 1.10 (0.80–1.51) | 0.87 (0.64–1.18) | |||
Stricturing | 0.67 (0.45–0.99) | 1.23 (0.84–1.81) | 0.67 (0.46–0.98) | |||
Penetrating | 1.00 (0.60–1.66) | 0.85 (0.52–1.40) | 1.15 (0.71–1.87) | |||
Ileal/Stricturing | 0.71 (0.45–1.13) | 1.44 (0.89–2.32) | 0.48 (0.29–(0.79) | |||
Colonic/Inflammatory | 0.61 (0.42–0.89) | 1.20 (0.84–1.72) | 0.82 (0.58–1.16) | |||
Any relative with IBD | 0.43 (0.25–0.73) | 0.72 (0.44–1.17) | 1.06 (0.68–1.66) | 1.37 (0.84–2.24) | 0.79 (0.51–1.22) | 0.57 (0.35–0.93) |
Bowel resection | 0.75 (0.52–1.08) | 0.91 (0.58–1.43) | 1.10 (0.77–1.58) | 0.88 (0.57–1.36) | 0.72 (0.50–1.03) | 1.28 (0.85–1.93) |
Smoker at diagnosis | 0.84 (0.56–1.26) | 1.16 (0.71–1.90) | 1.40 (0.92–2.14) | 1.09 (0.65–1.83) | 0.69 (0.46–1.03) | 0.75 (0.45–1.26) |
Ever used immunomodulators | 0.70 (0.50–0.98) | 0.90 (0.59–1.36) | 1.18 (0.85–1.64) | 1.10 (0.72–1.67) | 0.81 (0.59–1.11) | 0.94 (0.63–1.40) |
Any EIMs | 0.60 (0.37–0.97) | 0.77 (0.48–1.24) | 1.08 (0.69–1.68) | 1.25 (0.77–2.02) | 0.93 (0.61–1.42) | 0.80 (0.51–1.27) |