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Table 4 Allelic odds ratios and 95% confidence intervals for comparison of NOD1/CARD4 variants with IBD status in New Zealand IBD patients and Caucasians

From: Nucleotide-binding oligomerization domain containing 1 (NOD1) haplotypes and single nucleotide polymorphisms modify susceptibility to inflammatory bowel diseases in a New Zealand caucasian population: a case-control study

  Allelic odds ratios and 95% confidence intervals for comparison of NOD1 rs2075818 Allelic odds ratios and 95% confidence intervals for comparison of NOD1 rs2075822 Allelic odds ratios and 95% confidence intervals for comparison of NOD1 rs2907748
  CD UC CD UC CD UC
  OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI)
Female 0.66 (0.46–0.96) 0.94 (0.65–1.36) 1.14 (0.79–1.64) 1.18 (0.81–1.71) 0.94 (0.66–1.34) 0.87 (0.60–1.25)
Male 0.66 (0.42–1.04) 1.02 (0.68–1.54) 1.03 (0.66–1.61) 1.33 (0.86–2.05) 0.71 (0.46–1.09) 0.76 (0.51–1.13)
Age at first diagnosis       
0–16 years 0.62 (0.33–1.15) 0.94 (0.48–1.83) 0.75 (0.44–1.28) 1.11 (0.56–2.20) 1.11 (0.65–1.90) 1.20 (0.65–2.23)
17–40 years 0.67 (0.48–0.94) 0.91 (0.66–1.26) 1.03 (0.75–1.42) 1.17 (0.84–1.64) 0.88 (0.64–1.20) 0.83 (0.60–1.14)
>40 years 0.66 (0.46–0.95) 1.06 (0.77–1.45) 1.36 (0.94–1.96) 1.36 (0.97–1.91) 0.72 (0.51–1.02) 0.78 (0.57–1.07)
CD location       
Ileal 0.82 (0.56–1.19)   1.15 (0.79–1.67)   0.71 (0.49–1.03)  
Colonic 0.59 (0.41–0.85)   1.22 (0.86–1.72)   0.80 (0.57–1.11)  
Ileocolonic 0.60 (0.38–0.94)   0.89 (0.60–1.33)   1.03 (0.69–1.53)  
UC location       
Proctitis   0.94 (0.67–1.32)   1.05 (0.74–1.49)   1.04 (0.75–1.44)
Left colon   1.14 (0.79–1.65)   1.43 (0.95–2.16)   0.85 (0.58–1.24)
Pancolitis   0.92 (0.65–1.31)   1.40 (0.96–2.03)   0.58 (0.40–0.84)
CD Behavior       
Inflammatory 0.59 (0.42–0.82)   1.10 (0.80–1.51)   0.87 (0.64–1.18)  
Stricturing 0.67 (0.45–0.99)   1.23 (0.84–1.81)   0.67 (0.46–0.98)  
Penetrating 1.00 (0.60–1.66)   0.85 (0.52–1.40)   1.15 (0.71–1.87)  
Ileal/Stricturing 0.71 (0.45–1.13)   1.44 (0.89–2.32)   0.48 (0.29–(0.79)  
Colonic/Inflammatory 0.61 (0.42–0.89)   1.20 (0.84–1.72)   0.82 (0.58–1.16)  
Any relative with IBD 0.43 (0.25–0.73) 0.72 (0.44–1.17) 1.06 (0.68–1.66) 1.37 (0.84–2.24) 0.79 (0.51–1.22) 0.57 (0.35–0.93)
Bowel resection 0.75 (0.52–1.08) 0.91 (0.58–1.43) 1.10 (0.77–1.58) 0.88 (0.57–1.36) 0.72 (0.50–1.03) 1.28 (0.85–1.93)
Smoker at diagnosis 0.84 (0.56–1.26) 1.16 (0.71–1.90) 1.40 (0.92–2.14) 1.09 (0.65–1.83) 0.69 (0.46–1.03) 0.75 (0.45–1.26)
Ever used immunomodulators 0.70 (0.50–0.98) 0.90 (0.59–1.36) 1.18 (0.85–1.64) 1.10 (0.72–1.67) 0.81 (0.59–1.11) 0.94 (0.63–1.40)
Any EIMs 0.60 (0.37–0.97) 0.77 (0.48–1.24) 1.08 (0.69–1.68) 1.25 (0.77–2.02) 0.93 (0.61–1.42) 0.80 (0.51–1.27)