Figure 1

Histograms derived from Gene Set Enrichment Analysis (GSEA) of chs2 Δ and myo1 Δ mutant strains. The cutoff for significantly regulated biological process categories was based on a p-value ≤ 0.0004 as described in the Methods section. Red lines or dots represent the distribution of genes of the specific category in the array. Black lines or dots represent the distribution of genes for all categories in the array. (A, top panel) Density versus t-value plots generated for significant biological process categories from the chs2 Δ strain. (A, bottom panel) t-value versus A-value plots for genes of the same biological process categories shown in (A, top panel). (B, top panel) Density versus t-value plots previously generated for significant biological process categories from the myo1 Δ strain [10]. (B, bottom panel) t-value versus A-value plots for genes of the same biological process categories shown in (B, top panel). The results shown in Figure 1B were previously published in BMC Genomics 2008, 9:34 [10].