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Table 1 Characteristics of five high-risk prostate cancer pedigrees showing linkage evidence to chromosome 13q, BRCA2 region1

From: No evidence of BRCA2 mutations in chromosome 13q-linked Utah high-risk prostate cancer pedigrees

Pedigree Identifier2 Max TLOD score on chr 13q Location of max TLOD on chr 13 # prostate cancer cases in pedigree (genotyped) # prostate cancer cases carrying segregating 13q haplotype3 Age at prostate cancer diagnosis (yrs)
9775803 1.423 23.0 cM 9(6) 7 57, 59, 61, 61, 64, 73, 74, 84, 87
9445402 1.191 23.0 cM 5(3) 5 60, 60, 78, 79, 82
9990205 1.050 36.0 cM 10(5) 3 59, 61, 62, 65, 66, 66, 70, 73, 77, 78
9434307 0.976 29.0 cM 12(6) 6, 74 52, 59, 59, 63, 63, 69, 72, 74, 75, 76, 80, 85
9435901 0.953 23.0 cM 6(1) 4 54, 57, 62, 64, 67, 82
  1. 1Pedigrees defined in Table 1 are based on the pedigree structure used for the linkage analysis.
  2. 2Pedigree identifier modified to protect confidentiality of pedigree members.
  3. 3Haplotype carrier status may be inferred based on descendant information rather than directly genotyped.
  4. 4Two distinct 13q haplotypes segregated within the pedigree.