Table 2 In vitro activity of antifungal agents against Candida spp. isolates from different clinical materials at the Brazilian Tertiary Hospital (Clinical Hospital of the UNESP School of Medicine, Botucatu, São Paulo State), from 1998 to 2005.
Isolates (n) | Drugsa | Cumulative % of isolates susceptible at a MIC (g/ml) ofd: | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0.03b | 0.06 | 0.125c | 0.25a | 0.5 | 1 | 2 | 4 | 8 | 16 | >16c | 32 | 64 | >64b | ||
C. albicans (70) | FLU | 5.7 | 30.0 | 40.0 | 65.7 | 74.3 | 80.0 | 84.3 | 92.9 | 100 | |||||
ITR | 57.1 | 71.4 | 84.3 | 87.1 | 88.6 | 88.6 | 90.0 | 90.0 | 90.0 | 90.0 | 100 | ||||
AMB | 21.0 | 64.0 | 100 | ||||||||||||
C. glabrata (25) | FLU | 4.0 | 16.0 | 32.0 | 92.0 | 100 | |||||||||
ITR | 4.0 | 4.0 | 8.0 | 12.0 | 32.0 | 48.0 | 56.0 | 60.0 | 76.0 | 100 | |||||
AMB | 16.0 | 100 | |||||||||||||
C. guilliermondii (10) | FLU | 30.0 | 30.0 | 80.0 | 90.0 | 90.0 | 90.0 | 100,0 | |||||||
ITR | 20.0 | 50.0 | 60.0 | 90.0 | 90.0 | 90.0 | 90.0 | 90.0 | 90.0 | 90.0 | 100 | ||||
AMB | 10.0 | 30.0 | 100 | ||||||||||||
C. parapsilosis (66) | FLU | 1.5 | 3.0 | 10.6 | 33.3 | 69.7 | 89.4 | 98.5 | 98.5 | 98.5 | 98.5 | 100 | |||
ITR | 69.7 | 90.9 | 97.0 | 97.0 | 98.5 | 98.5 | 98.5 | 98.5 | 98.5 | 98.5 | 100 | ||||
AMB | 1.5 | 6.1 | 98.5 | 100 | |||||||||||
C. tropicalis (38) | FLU | 2.6 | 7.9 | 31.6 | 44.7 | 60.5 | 76.3 | 81.6 | 81.7 | 81.8 | 81.9 | 81.10 | 100 | ||
ITR | 21.1 | 31.6 | 55.3 | 68.4 | 73.7 | 78.9 | 84.2 | 84.2 | 84.2 | 84.2 | 100 | ||||
AMB | 21.0 | 100 | |||||||||||||
All Candida speciese (212) | FLUa | 2.8 | 11.3 | 17.9 | 37.7 | 57.1 | 67.9 | 80.7 | 86.3 | 88.2 | 94.3 | 100 | |||
ITRb | 45.3 | 61.3 | 72.2 | 77.8 | 79.7 | 83.0 | 86.3 | 87.3 | 87.7 | 90.1 | 100 | ||||
AMB | 8.0 | 30.7 | 99.5 | 100 | |||||||||||