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Table 2 Description of empiric therapy *.

From: Clinical outcome of empiric antimicrobial therapy of bacteremia due to extended-spectrum beta-lactamase producing Escherichia coli and Klebsiella pneumoniae

FACTOR

CASE FATALITY WITH FACTOR

CASE FATALITY WITHOUT FACTOR

RELATIVE RISK (95% CI)

P-VALUE

Empiric by t = 0

7/29 (24%)

9/50 (18%)

1.34 (0.56-3.22)

NS

Empiric by t = 8 hours

12/48 (25%)

4/31 (13%)

1.94 (0.69-5.47)

NS

Empiric by t = 24 hours

14/68 (21%)

2/11 (18%)

1.13 (0.30-4.32)

NS

Empiric by t = 48 hours

15/74 (20%)

1/5 (20%)

1.01 (0.17-6.20)

NS

Empiric at t > 48 hours

0/3 (0%)

16/76 (21%)

0.00

NS

Never received empiric therapy.

0/1 (0%)

16/78 (21%)

...

...

Empiric Treatment Class

    

Carbapenem

0/10 (0%)

16/69 (24%)

0.00 ()

0.09

Aminoglycoside

1/7 (14%)

15/72 (21%)

0.67 (0.10-4.41)

NS

Fluoroquinolone

3/13 (23%)

13/66 (20%)

1.17 (0.39-3.54)

NS

Beta-lactam/Beta-lactamase inhibitor combination

6/16 (38%)

10/63 (16%)

2.36 (1.01-5.53)

0.06

Cephalosporin

5/30 (17%)

11/49 (22%)

0.74 (0.29-1.93)

NS

Beta-lactam

0/5 (0%)

16/74 (22%)

0.00 ()

NS

  1. * Empiric therapy was defined as that therapy initiated prior to the availability of blood culture results and sensitivities.