Figure 1

Multiple sequence alignment of c-kit juxtamembrane domain. Multiple sequence alignment in combination with phylogenetic tree was generated by PIR-ALN for Kit kinase with other kinase family members. Alignments show dual tyrosine containing conserved Y568V569Y570 stretch of residues in "EEINGNNYVYIDP" motif, which is used as a docking platform for SH2 and SH3 domain containing proteins.