Figure 4

Analysis of docked complexes and H-bond interactions between ligand and substrate ( 2shp-1pgk.pdb). A. The docked complex show two SH2 domains as ribbons (pale golden color) and the blue color ball and stick structures show the residues of SH2 domains that interacted with Kit catalytic residues (stretch of violet color). The golden color displays the groove like structure in Kit catalytic domain. B. H-bonds are detected between SH2 domains and Kit cytoplasmic domain. Discontinuous white lines appear as the H-bonds between SH2 domain residues (red color ball and sticks) and Kit kinase lobe (pink color ball and sticks) residues. The white background displays important hydrogen bonding between Kit activation loop residues comprising Lys818 to Ser821 and N-sh2 domain residues.