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Table 1 Residues found to be predominantly closer between N-sh2 and c-Kit

From: The structural insights of stem cell factor receptor (c-Kit) interaction with tyrosine phosphatase-2 (Shp-2): An in silico analysis

Repulsion values for docking (A°) Residues found closer in Shp-2 bound Kit c-Kit: N-sh2 Distance observed c-Kit: N-sh2 (A°) Domains interacting
6.6 Ile571-Asp26 8.59 Kit Juxtamembrane and PY pocket
6.6 Val569-Tyr100 7.07 Kit Juxtamembrane and N-sh2
6.6 Asp816-Tyr100 4.68 Kit activation loop and N-sh2
6.4 Ile571-Tyr100 5.66 Kit Juxtamembrane and N-sh2
6.4 Val569-Tyr100 4.46 Kit Juxtamembrane and N-sh2
6.6 Asp816-Tyr100 6.17 Kit activation loop and N-sh2
  1. Repulsion values 6.6 and 6.4 A° show that conserved Juxtamembrane residues and activation loop residues are predominantly closer to N-sh2 domain residues.