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Table 1 Residues found to be predominantly closer between N-sh2 and c-Kit

From: The structural insights of stem cell factor receptor (c-Kit) interaction with tyrosine phosphatase-2 (Shp-2): An in silico analysis

Repulsion values for docking (A°)

Residues found closer in Shp-2 bound Kit c-Kit: N-sh2

Distance observed c-Kit: N-sh2 (A°)

Domains interacting

6.6

Ile571-Asp26

8.59

Kit Juxtamembrane and PY pocket

6.6

Val569-Tyr100

7.07

Kit Juxtamembrane and N-sh2

6.6

Asp816-Tyr100

4.68

Kit activation loop and N-sh2

6.4

Ile571-Tyr100

5.66

Kit Juxtamembrane and N-sh2

6.4

Val569-Tyr100

4.46

Kit Juxtamembrane and N-sh2

6.6

Asp816-Tyr100

6.17

Kit activation loop and N-sh2

  1. Repulsion values 6.6 and 6.4 A° show that conserved Juxtamembrane residues and activation loop residues are predominantly closer to N-sh2 domain residues.