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Table 4 Cytochrome c oxidase activity of mouse liver and brain mitochondria exposed to different free bilirubin (Bf) concentrations

From: Effect of bilirubin on cytochrome c oxidase activity of mitochondria from mouse brain and liver

   Percent Activity (%) vs controla
[UCB]
[HSA]b
Range of Bf (nM) BMc LMd
0.20 22-31 105 ± 3.1 101 ± 1.8
0.35 60-61 104 ± 8.9 99.1 ± 3.1
0.50 92-107 82.0 ± 4.5e 84.9 ± 3.5e
0.75 142-150 82.6 ± 1.0e 80.7 ± 5.8e
  1. aResults are means of three repeats of at least three separate measurements of the activity of cytochrome c oxidase activity as percent of control (no UCB). bMolar ratios of bilirubin to albumin (r). cMouse liver mitochondria. dMouse brain mitochondria. eAll p < 0.001 vs. Bf = 22-31 nM, and p < 0.05 vs Bf = 60-61 nM, respectively. No significant differences between: Bf = 22-31 nM vs. Bf = 60-61 nM (p = 0.936 for BM and p = 0.302 for LM); Bf = 92-107 nM vs. Bf = 142-150 nM (p = 0.791 for BM and p = 0.342 for LM); or BM vs. LM at any range of Bf (p = 0.086, p = 0.372, p = 0.298, p = 0.605, respectively).