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Table 4 Cytochrome c oxidase activity of mouse liver and brain mitochondria exposed to different free bilirubin (Bf) concentrations

From: Effect of bilirubin on cytochrome c oxidase activity of mitochondria from mouse brain and liver

  

Percent Activity (%) vs controla

[UCB]

[HSA]b

Range of Bf (nM)

BMc

LMd

0.20

22-31

105 ± 3.1

101 ± 1.8

0.35

60-61

104 ± 8.9

99.1 ± 3.1

0.50

92-107

82.0 ± 4.5e

84.9 ± 3.5e

0.75

142-150

82.6 ± 1.0e

80.7 ± 5.8e

  1. aResults are means of three repeats of at least three separate measurements of the activity of cytochrome c oxidase activity as percent of control (no UCB). bMolar ratios of bilirubin to albumin (r). cMouse liver mitochondria. dMouse brain mitochondria. eAll p < 0.001 vs. Bf = 22-31 nM, and p < 0.05 vs Bf = 60-61 nM, respectively. No significant differences between: Bf = 22-31 nM vs. Bf = 60-61 nM (p = 0.936 for BM and p = 0.302 for LM); Bf = 92-107 nM vs. Bf = 142-150 nM (p = 0.791 for BM and p = 0.342 for LM); or BM vs. LM at any range of Bf (p = 0.086, p = 0.372, p = 0.298, p = 0.605, respectively).