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Table 3 Prognostic parameters on univariate and multivariate analysis for lung cancer patients

From: Factors of interrupting chemotherapy in patients with Advanced Non-Small-Cell Lung Cancer

  Univariate analysis Multivariate analysis
  HR 95% CI p HR 95% CI p
ECOG Performance Status assessed by the physician
0-1
>1
3.641 [1.743-7.607] 0.0006 3.279 [1.546-6.955] 0.0020
Hemoglobin
Normal
Abnormal†
2.941 [1.401-6.172] 0.0044 2.781 [1.290-5.997] 0.0091
Platelet count (G/L)
≥130
<130
4.023 [1.512-10.703] 0.0053    NS
Weight loss >10%
No
Yes
2.633 [1.079-6.423] 0.0334    NS
Number of metastases
≤2
>2
1.776 [0.913-3.453] 0.0904    NS
Number of chemotherapy lines
≤1
>1
   0.0305    NS
Albumin (g/L)
≥38
<38
1.585 [0.722-3.481] 0.2510    -
CRP (mg/L)
≤10
>10
1.499 [0.718-3.132] 0.2812    -
Lymphocyte Count
≥700/μL
<700/μL
1.297 [0.684-2.462] 0.4258    -
Liver metastases
No
Yes
0.809 [0.415-1.581] 0.5359    -
Quality of life using 0-10 VAS
≥5
<5
0.841 [0.445-1.592] 0.5953    -
Age (years)
≤60
>60
0.919 [0.495-1.710] 0.7907    -
Previous adjuvant chemotherapy
No
Yes
0.863 [0.265-2.816] 0.8074    -
LDH (U/L)
≤600
>600
1.079 [0.501-2.326] 0.8462    -
Absolute Neutrophil Count
≥2
<2
1.190 [0.161-8.801] 0.8648    -
  1. LDH: lactate dehydrogenase; CRP: C-reactive protein; VAS: visual analog scale. †<11.5 g/dL for female; <13.0 g/dL for male