TY - JOUR AU - Provazzi, Paola JS AU - Arcuri, Helen A. AU - de Carvalho-Mello, Isabel Maria VG AU - Pinho, João Renato R. AU - Nogueira, Maurício L. AU - Palma, Mário S. AU - Rahal, Paula PY - 2010 DA - 2010/07/14 TI - Structural studies of Helicase NS3 variants from Hepatitis C virus genotype 3 in virological sustained responder and non-responder patients JO - BMC Research Notes SP - 196 VL - 3 IS - 1 AB - About 130 million people are infected with the hepatitis C virus (HCV) worldwide, but effective treatment options are not yet available. One of the most promising targets for antiviral therapy is nonstructural protein 3 (NS3). To identify possible changes in the structure of NS3 associated with virological sustained response or non-response of patients, a model was constructed for each helicase NS3 protein coding sequence. From this, the goal was to verify the interaction between helicases variants and their ligands. SN - 1756-0500 UR - https://doi.org/10.1186/1756-0500-3-196 DO - 10.1186/1756-0500-3-196 ID - Provazzi2010 ER -