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Table 2 Genotypic frequency distribution of MTHFR and statistically significant clinical variables in relation to MTHFR genotype

From: Analysis of the MTHFR C677T variant with migraine phenotypes

Clinical variables Subtype (Total) MTHFR Genotype %
   CC CT TT
Migraine Diagnosis MO (102) 39 (39%) 61 (45%) 2 (6%)
P < 0.0001 MA (165) 61 (61%) 74 (55%) 30 (94%)
Unilateral head pain Y (123) 40 (62%) 63 (77%) 20 (87%)
P < 0.0001 N (47) 25 (38%) 19 (23%) 3 (13%)
Physical activity Y (149) 51 (69%) 78 (88%) 20 (83%)
P < 0.001 N (38) 23 (31%) 11 (12%) 4 (17%)
Stress Y (123) 42 (61%) 68 (76%) 13 (52%)
P = 0.002 N (60) 27 (39%) 21 (24%) 12 (48%)
  1. Significant P values after correction for multiple testing (Bonferroni correction).
  2. MO = Migraine without aura, MA = Migraine with aura, Y = Yes and N = No.