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Figure 2 | BMC Research Notes

Figure 2

From: Alpha-santalol, a chemopreventive agent against skin cancer, causes G2/M cell cycle arrest in both p53-mutated human epidermoid carcinoma A431 cells and p53 wild-type human melanoma UACC-62 cells

Figure 2

Effects of α-santalol on the distribution of A431 cells in the different phases of the cell cycle. A431 Cells were treated with α-santalol (0 μM-75 μM) for 6 h (A and B), 12 h (C and D) and 24 h (E and F). At the end of respective treatment, cells were harvested and digested with RNase. Cellular DNA was stained with propidium iodide and analyzed by flow cytometer as described in the Materials and Methods. Panels A, C and E are histograms representing different time treatment with α-santalol. Data in Panel B, D and F from the cell cycle distribution were summarized and presented as the mean ± SD of three observations. *, P < 0.05 indicates statistical significance in α-sanatlol treated groups as compared to the control in A431 cells.

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