Figure 1From: NOD2-C2 - a novel NOD2 isoform activating NF-κB in a muramyl dipeptide-independent mannerSchematic transcript and protein representation of NOD2 and its isoforms NOD2-S as well as NOD2-C2. The novel NOD2-C2 transcript contains an additional exon 3a highlighted in black. Contrary to NOD2-S, NOD2-C2 has a reconstructed second CARD domain, which differs in the last 9 amino acid compared to exon 3-4 spliced NOD2.Back to article page