Data-mining interface. The "Filter gene set" data-mining interface allows users to select a gene set that meets specific expression, keyword, and sequence criteria. Input fields include a) differential expression quantified from stage-specific expression microarray analyses, b) keywords included in functional annotation gathered by AegyXcel http://exon.niaid.nih.gov/transcriptome.html#aegyxcel from the ENSEMBL, NCBI non-redundant, PFAM, GO, and SMART databases, and c) DNA sequences contained within promoter, 5' untranslated region, 3' untranslated region, or cDNA sequences from the Ae. aegypti genome. Each filter is imposed on the current gene set being examined, beginning with the entire Ae. aegypti genome, thus selecting and reducing the gene set in a stepwise fashion as genes matching previous filter criteria are eliminated by subsequent filters. The parameters and gene set shown here are those corresponding to the prophenoloxidase case study described in the text.