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Table 1 Comparison of nested PCR and 2-tier serology in detection of Lyme disease among 333 patients referred by private practitioners from offices

From: Early Lyme disease with spirochetemia - diagnosed by DNA sequencing

  Two-tier Serology Total
  + -  
Nested PCR + 0 0 0
Nested PCR - 28 305 333
Total 28 305 333
  1. + = positive
  2. - = negative
  3. Laboratory detection of Lyme disease among 333 patients referred from private offices:
  4. Confirmed case prevalence = 28/333 = 8.4% (2-tier serology only)
  5. Sensitivity of nested PCR = 0% (0/28)
  6. Sensitivity of 2-tier seropositivity = 100% (28/28)