TY - JOUR AU - Hagemann, Carsten AU - Anacker, Jelena AU - Haas, Stefanie AU - Riesner, Daniela AU - Schömig, Beate AU - Ernestus, Ralf-Ingo AU - Vince, Giles H. PY - 2010 DA - 2010/11/10 TI - Comparative expression pattern of Matrix-Metalloproteinases in human glioblastoma cell-lines and primary cultures JO - BMC Research Notes SP - 293 VL - 3 IS - 1 AB - Glioblastomas (GBM), the most frequent malignant brain tumors in adults, are characterized by an aggressive local growth pattern and highly invasive tumor cells. This invasion is facilitated by expression of matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases. They mediate the degradation of protein components of the extracellular matrix. Twenty-three family members are known. Elevated levels of several of them have been reported in GBM. GBM cell-lines are used for in vitro studies of cell migration and invasion. Therefore, it is essential to know their MMP expression patterns. Only limited data for some of the cell-lines are published, yet. To fill the gaps in our knowledge would help to choose suitable model systems for analysis of regulation and function of MMPs during GBM tumorigenesis, cell migration and invasion. SN - 1756-0500 UR - https://doi.org/10.1186/1756-0500-3-293 DO - 10.1186/1756-0500-3-293 ID - Hagemann2010 ER -