Figure 3

shows the comparative KC-SMARTR graphical output, run on the B- and T-cell lymphoma dataset. The black line represents the B-cell lymphomas and the red line the T-cell lymphomas. Using a kernel width of 200 kb and an FDR of 5%, the VDJ regions can clearly be distinguished as significantly lost in the B-cells on chromosome 2, 14 and 22 and as significantly lost in the T-cells on chromosomes 7 and 14. The green bars indicate the approximate positions of the immunoglobulin variable regions, the purple bars indicate T-cell receptor variable regions. Also see Table 1 for a list of identified regions over the entire genome.