Identification of 5 novel germline APC mutations and characterization of clinical phenotypes in Japanese patients with classical and attenuated familial adenomatous polyposis

Table 2 Prediction of the effects of the c.1958G > C mutation on splicing

Allele	Splice prediction¹	ESE score for SC35²
Wild type (G)	0.91	4.595
Mutant type (C)	< 0.01	-³

¹Predicted by the Berkeley Drosophila Genome Project (BDGP) splice prediction program.
²Exonic splicing enhancer (ESE) score as predicted by ESEfinder. Its threshold score for SC35 protein is 2.383.
³Below the threshold score.

ISSN: 1756-0500