Figure 3
Hearts from PKA Cβ null mice are resistant to hypertrophic effects of angiotensin. A. Heart weights of WT and PKA Cβ null mice, before and after treatment with angiotensin II. Hearts of unchallenged mice showed similar weights regardless of genotype, but hearts of WT mice after angiotensin II treatment were significantly larger that those of PKA Cβ null littermates. Heart weights standardized to tibia length. n = 7 per genotype; error bars represent standard deviations. Probabilities < 0.05 indicated on graph. B. Hearts of angiotensin II-treated WT mice were visibly larger than those of Cβ null littermates. Echocardiographical measurements of LVMI were confirmed both visually and by weighing the hearts; the angiotensin II-treated WT heart on the left was found using echocardiography to have an LVMI of 4.07 while the challenged Cβ null heart on the right was found to have an LVMI of only 2.15.