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Table 1 Clinical characteristics of patients

From: Alpha-1-acid glycoprotein as potential biomarker for alpha-fetoprotein-low hepatocellular carcinoma

Variable Control (n= 96) HCC (n= 124) P-value (vs. control)
  Chronic Hepatitis ( n = 49) Cirrhosis ( n = 47) AFP ≤ 20 ng/mL ( n = 61) AFP > 20 ng/mL ( n = 63) AFP-Low HCC AFP-high HCC
Age 42.4 ± 14.9 53.8 ± 9.2 55.8 ± 14.6 53.5 ± 12.9 0.0008 0.0127
Gender (M:F) 25:24 31:16 41:20 51:12 0.2659 0.0030
Etiology (%)      0.0124 0.2458
HBV 69.4 48.9 47.5 66.7   
HCV 30.6 36.2 19.7 28.6   
Non HBV-non-HCV 0 14.9 32.8 4.8   
AST (IU/mL) 32.5 (12-194) 42 (16-110) 91 (5-714) 138 (9-945) 0.0026 < 0.0001
ALT (IU/mL) 32.5 (6-868) 32 (15-63) 46 (8-363) 65 (6-347) < 0.0001 < 0.0001
  1. Data presented as mean ± SD or median (range)
  2. HCC, hepatocellular carcinoma; HBV, hepatitis B virus; HCV, hepatitis C virus; AFP, α-fetoprotein; AST, aspartate aminotransferase; ALT, alanine aminotransferase