Figure 2

MethVisual example. (a) Lollipop displays for 4 binarized methylation profiles in the genomic context are shown. Filled dots refer to methylated sites, empty dots to non methylated sites. Each clone of the experiment is displayed separately according to its methylation status. Lengths of the connecting lines correspond to relative genomic distance between CpG sites. A summary plot is given in the upper part of the figure. The percentage of filling of each dot corresponds to the percentage of clones that showed methylation of the respective CpG site. Furthermore, in the summary plot, the thickness of the connecting lines between each two CpG sites refers to the correlation of methylation between the two neighbouring CpG sites. (b) Example of distant co-occurrence plot. CpG sites are displayed in a matrix. Each pairwise comparison, e.g. neighbouring and distant, leads to a correlation value that is displayed in the matrix. Correlation is color coded and the color coding bar is given beside the graph. The numbers in the diagonal give the genomic position of each displayed CpG site (c) Example of correspondence analysis plot. The first two components of correspondence plot of co-occurrence are shown. Red triangles refer to the position of CpG sites, black bullets to clones under study. At the x and y axes correspondence component inertia of 85.71% and 14.29% are given.