The usefulness of immunohistochemistry in tissue microarrays of Human Papillomavirus negative adenocarcinoma of the uterine cervix

Table 2 Immunohistochemistry patterns by HPV positivity in archival adenocarcinoma samples from Uganda*

HPV positive (N = 12/25)				HPV negative (N = 13/25)
CEA	Vimentin	ER	PR	% with this pattern	% with this pattern	Histological subtype
+	-	-	-	58.3% (7/12)	38.5% (5/13)	Mucinous Intestinal (2) Mucinous Endocervical (1) Mucinous NOS (1) NOS (1)
-	+	-	+	16.7% (2/12)	0.0% (0/13)	-
-	+	-	-	8.3% (1/12)	23.1% (3/13)	Mucinous Endocervical (1) NOS (2; probable endometrial)^†
-	-	-	-	16.7% (2/12)	38.5% (5/13)	Mucinous Endocervical (1) Mucinous Villoglandular (1) NOS (1)^†,§ Serous (2; probable endometrial)^†

*Out of the 26 samples 25 were stained with all the antibodies and HPV tested
^†After immunohistochemistry and histological subtype diagnosis an endometrial origin cannot be discarded
^§No further classification because of lack of markers

ISSN: 1756-0500