TY - JOUR AU - Lakhan, Shaheen E. AU - Callaway, Enoch PY - 2010 DA - 2010/03/04 TI - Deep brain stimulation for obsessive-compulsive disorder and treatment-resistant depression: systematic review JO - BMC Research Notes SP - 60 VL - 3 IS - 1 AB - In spite of advances in psychotherapy and pharmacotherapy, there are still a significant number of patients with depression and obsessive-compulsive disorder that are not aided by either intervention. Although still in the experimental stage, deep brain stimulation (DBS) offers many advantages over other physically-invasive procedures as a treatment for these psychiatric disorders. The purpose of this study is to systematically review reports on clinical trials of DBS for obsessive-compulsive disorder (OCD) and treatment-resistant depression (TRD). Locations for stimulation, success rates and effects of the stimulation on brain metabolism are noted when available. The first observation of the effects of DBS on OCD and TRD came in the course of using DBS to treat movement disorders. Reports of changes in OCD and depression during such studies are reviewed with particular attention to electrode locations and associated adverse events; although these reports were adventitious observations rather than planned. Subsequent studies have been guided by more precise theories of structures involved in DBS and OICD. This study suggests stimulation sites and prognostic indicators for DBS. We also briefly review tractography, a relatively new procedure that holds great promise for the further development of DBS. SN - 1756-0500 UR - https://doi.org/10.1186/1756-0500-3-60 DO - 10.1186/1756-0500-3-60 ID - Lakhan2010 ER -