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Table 3 Results of collagen-induced aggregometry for the 3 treatment groups

From: Is there an ideal way to initiate antiplatelet therapy with aspirin? A crossover study on healthy volunteers evaluating different dosing schemes with whole blood aggregometry

  Aspirin 200 mg oral Aspirin 500 mg oral Aspirin 500 mg i.v. P-value (200 mg vs. 500 mg oral)
basal 16.9 (14.4-19.5) 20.1 (16.0-24.1) 21.4 (19.2-23.6) 0.19
0.5 min - - 15.9 (13.4-18.4) -
1 min - - 17.0 (14.7-19.3) -
2.5 min - - 16.7 (14.1-19.2) -
5 min 17.1 (14.5-19.7) 18.8 (15.3-22.2) 16.2 (13.4-19.0) 0.49
7.5 min - - 17.0 (12.8-21.2) -
10 min 15.8 (12.2-19.5) 19.6 (15.5-23.6) 18.8 (13.2-24.4) 0.19
15 min 15.2 (11.3-19.0) 19.8 (16.0-23.7) 16.6 (9.1-24.1) 0.14
30 min 14.6 (10.5-18.7) 13.7 (9.0-18.4) 17.8 (15.1-20.5) 0.77
45 min 12.6 (8.6-16.6) 12.3 (7.0-17.6) 12.8 (2.6-22.9) 0.79
60 min 11.8 (8.3-15.2) 13.0 (7.2-18.8) 16.8 (11.7-21.9) 0.74
120 min 14.7 (11.0-18.4) 16.2 (10.6-21.9) 17.4 (11.9-22.6) 0.68
180 min 14.0 (10.7-17.3) 15.7 (6.5-24.8) 16.8 (9.8-23.8) 0.69
240 min 14.4 (7.7-21.1) 13.3 (3.0-23.7) 18.6 (14.2-23.0) 0.82
Day 2 14.8 (11.4-18.1) 14.8 (8.5-21.1) 16.0 (13.1-18.9) 0.59
  1. Values in ohm (Ω) with mean (95% CI); significance was tested by using the paired Student's t test under the Bonferroni-adjusted significance level of p = 0.0045 (= 0.05/11) for multiple comparisons. vs - versus.