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Table 3 Results of collagen-induced aggregometry for the 3 treatment groups

From: Is there an ideal way to initiate antiplatelet therapy with aspirin? A crossover study on healthy volunteers evaluating different dosing schemes with whole blood aggregometry

 

Aspirin 200 mg oral

Aspirin 500 mg oral

Aspirin 500 mg i.v.

P-value (200 mg vs. 500 mg oral)

basal

16.9 (14.4-19.5)

20.1 (16.0-24.1)

21.4 (19.2-23.6)

0.19

0.5 min

-

-

15.9 (13.4-18.4)

-

1 min

-

-

17.0 (14.7-19.3)

-

2.5 min

-

-

16.7 (14.1-19.2)

-

5 min

17.1 (14.5-19.7)

18.8 (15.3-22.2)

16.2 (13.4-19.0)

0.49

7.5 min

-

-

17.0 (12.8-21.2)

-

10 min

15.8 (12.2-19.5)

19.6 (15.5-23.6)

18.8 (13.2-24.4)

0.19

15 min

15.2 (11.3-19.0)

19.8 (16.0-23.7)

16.6 (9.1-24.1)

0.14

30 min

14.6 (10.5-18.7)

13.7 (9.0-18.4)

17.8 (15.1-20.5)

0.77

45 min

12.6 (8.6-16.6)

12.3 (7.0-17.6)

12.8 (2.6-22.9)

0.79

60 min

11.8 (8.3-15.2)

13.0 (7.2-18.8)

16.8 (11.7-21.9)

0.74

120 min

14.7 (11.0-18.4)

16.2 (10.6-21.9)

17.4 (11.9-22.6)

0.68

180 min

14.0 (10.7-17.3)

15.7 (6.5-24.8)

16.8 (9.8-23.8)

0.69

240 min

14.4 (7.7-21.1)

13.3 (3.0-23.7)

18.6 (14.2-23.0)

0.82

Day 2

14.8 (11.4-18.1)

14.8 (8.5-21.1)

16.0 (13.1-18.9)

0.59

  1. Values in ohm (Ω) with mean (95% CI); significance was tested by using the paired Student's t test under the Bonferroni-adjusted significance level of p = 0.0045 (= 0.05/11) for multiple comparisons. vs - versus.