Figure 7
From: Searching the protein structure database for ligand-binding site similarities using CPASS v.2
ROC curves showing the true positive rate relative to the false positive rate of CPASS calculations for (A) aspartate transaminases (EC 2.6.1.1) and (B) glutamine-tRNA ligases (EC 6.1.1.18). True positives are defined based on three levels of functional homology between the query protein and the CPASS database. ROC curve with true positives based on an exact EC classification (all four E.C. numbers are identical) is colored blue. ROC curve with true positives based on a broad EC classification (only first three E.C. numbers are identical) is colored red. ROC curve with true positives based simply on proteins binding the same ligand is colored green. Distribution curves showing the fraction of negatives (red) and positives (blue) as a function of CPASS similarity scores (bin size of 10) are shown for (C) aspartate transaminases (EC 2.6.1.1) and (D) glutamine-tRNA ligases (EC 6.1.1.18).