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Table 2 Summary results according to different models of analysis for the seven strongest association signals obtained by a meta-analysis of three independent genome-wide association studies in Alzheimer's disease (TGen data sets, Reiman dise et al. 2007)

From: A note on the use of the generalized odds ratio in meta-analysis of association studies involving bi- and tri-allelic polymorphisms

SNP Chr Gene MAFa Model of analysis OR (95% IC) P-value P(Q) I 2
      Fixed Random Fixed Random   
rs41377151 19q13.32 APOC1(3'region) 0.30 Allelic 3.00 (2.50-3.59) 3.15 (2.20-4.53) 2.14 × 10-32 4.65 × 10-10 0.05 67
     LAT 2.94 (2.43-3.56) 3.06 (2.12-4.43) 1.62 × 10-28 2.79 × 10-9 0.05 66
     GOR 3.44 (2.79-4.25) 3.64 (2.38-5.57) 1.73 × 10-30 2.73 × 10-9 0.04 68
     Domi 3.51 (2.81-4.40) 3.78 (2.35-6.08) 3.33 × 10-28 4.19 × 10-8 0.04 70
     Rece 5.51 (3.32-9.14) 5.51 (3.32-9.14) 4.31 × 10-11 4.31 × 10-11 0.59 0
rs17330779b 7q31 NRCAM (intron) 0.10 Allelic 0.53 (0.41-0.69) 0.53 (0.41-0.69) 1.61 × 10-6 1.61 × 10-6 0.42 0
     LAT 0.50 (0.38-0.65) 0.50 (0.38-0.65) 5.96 × 10-7 5.96 × 10-7 0.38 0
     GOR 0.49 (0.37-0.65) 0.49 (0.37-0.65) 4.72 × 10-7 4.72 × 10-7 0.42 0
     Domi 0.49 (0.37-0.65) 0.49 (0.37-0.65) 5.01 × 10-7 5.01 × 10-7 0.44 0
     Rece - - - - - -
rs10824310b 10q11.23 PRKG1 (intron) 0.06 Allelic 0.47 (0.35-0.64) 0.47 (0.35-0.64) 2.11 × 10-6 2.11 × 10-6 0.63 0
     LAT 0.45 (0.33-0.62) 0.45 (0.33-0.62) 1.41 × 10-6 1.41 × 10-6 0.56 0
     GOR 0.44 (0.31-0.61) 0.44 (0.31-0.61) 7.37 × 10-7 7.37 × 10-7 0.67 0
     Domi 0.43 (0.31-0.60) 0.43 (0.31-0.60) 7.04 × 10-7 7.04 × 10-7 0.68 0
     Rece - - - - - -
rs12162084 16 Unknown 0.16 Allelic 0.61 (0.50-0.75) 0.61 (0.50-0.75) 2.28 × 10-6 2.28 × 10-6 1.00 0
     LAT 0.59 (0.48-0.73) 0.59 (0.48-0.73) 1.56 × 10-6 1.56 × 10-6 0.99 0
     GOR 0.56 (0.45-0.71) 0.56 (0.45-0.71) 9.50 × 10-7 9.50 × 10-7 0.94 0
     Domi 0.56 (0.44-0.70) 0.56 (0.44-0.70) 1.15 × 10-6 1.15 × 10-6 0.84 0
     Rece 0.55 (0.26-1.15) 0.52 (0.17-1.60) 1.13 × 10-1 2.55 × 10-1 0.22 34
rs7077757 10q25.2 RBM20 (intron) 0.21 Allelic 0.64 (0.53-0.77) 0.64 (0.53-0.77) 2.45 × 10-6 2.45 × 10-6 0.92 0
     LAT 0.62 (0.51-0.76) 0.62 (0.51-0.76) 2.10 × 10-6 2.10 × 10-6 0.99 0
     GOR 0.59 (0.47-0.73) 0.59 (0.47-0.73) 1.34 × 10-6 1.34 × 10-6 0.99 0
     Domi 0.57 (0.46-0.72) 0.57 (0.46-0.72) 1.85 × 10-6 1.85 × 10-6 0.94 0
     Rece 0.58 (0.34-1.00) 0.57 (0.30-1.10) 4.81 × 10-2 9.25 × 10-2 0.29 20
rs10747758 12q14.2 OR6U2P 0.37 Allelic 0.69 (0.58-0.81) 0.69 (0.58-0.81) 3.97 × 10-6 3.97 × 10-6 0.50 0
     LAT 0.68 (0.57-0.80) 0.68 (0.57-0.80) 4.01 × 10-6 4.01 × 10-6 0.53 0
     GOR 0.62 (0.51-0.76) 0.62 (0.51-0.76) 2.04 × 10-6 2.04 × 10-6 0.52 0
     Domi 0.58 (0.46-0.73) 0.58 (0.46-0.73) 3.40 × 10-6 3.40 × 10-6 0.67 0
     Rece 0.66 (0.48-0.90) 0.66 (0.48-0.90) 9.70 × 10-3 9.70 × 10-3 0.54 0
rs2517509b 6p21.33 HCG22 0.03 Allelic 3.22 (1.94-5.34) 3.22 (1.94-5.34) 5.77 × 10-6 5.77 × 10-6 0.45 0
     LAT 3.27 (1.96-5.46) 3.30 (1.93-5.63) 5.85 × 10-6 1.27 × 10-5 0.35 4.7
     GOR 3.31 (1.97-5.57) 3.33 (1.95-5.70) 6.58 × 10-6 1.14 × 10-5 0.36 3.3
     Domi 3.31 (1.96-5.58) 3.32 (1.94-5.69) 7.53 × 10-6 1.19 × 10-5 0.36 2.8
     Rece - - - - - -
  1. aMAF, study size-weighted average minor allelic frequency. OR, odds ratio. 95% CI, 95% confidence intervals. Allelic, per-allele odds ratio. LAT, log-additive trend. GOR, generalized odds ratio. Domi, dominant. Rece, recessive. P(Q), P-value for the Cochran Q-statistic. Chr, chromosome. APOC1, Apolipoprotein C1. NRCAM, neuronal cell adhesion molecule. PRKG1, protein kinase, cGMP-dependent, type I. RBM20, RNA binding motif protein 20. OR6U2P, olfactory receptor, family 6, subfamily U, member 2 pseudogene. HCG22, HLA complex group 22. bFor the rs17330779, rs10824310 and rs2517509 variants, analyses under a recessive model were not possible due to the small minor allelic frequency (i.e. sparse data). Results are based on crude odds ratios (i.e. individual study estimates were not adjusted for gender and APOE status).