Table 2 Summary results according to different models of analysis for the seven strongest association signals obtained by a meta-analysis of three independent genome-wide association studies in Alzheimer's disease (TGen data sets, Reiman dise et al. 2007)
SNP | Chr | Gene | MAFa | Model of analysis | OR (95% IC) | P-value | P(Q) | I 2 | ||
|---|---|---|---|---|---|---|---|---|---|---|
Fixed | Random | Fixed | Random | |||||||
rs41377151 | 19q13.32 | APOC1(3'region) | 0.30 | Allelic | 3.00 (2.50-3.59) | 3.15 (2.20-4.53) | 2.14 × 10-32 | 4.65 × 10-10 | 0.05 | 67 |
LAT | 2.94 (2.43-3.56) | 3.06 (2.12-4.43) | 1.62 × 10-28 | 2.79 × 10-9 | 0.05 | 66 | ||||
GOR | 3.44 (2.79-4.25) | 3.64 (2.38-5.57) | 1.73 × 10-30 | 2.73 × 10-9 | 0.04 | 68 | ||||
Domi | 3.51 (2.81-4.40) | 3.78 (2.35-6.08) | 3.33 × 10-28 | 4.19 × 10-8 | 0.04 | 70 | ||||
Rece | 5.51 (3.32-9.14) | 5.51 (3.32-9.14) | 4.31 × 10-11 | 4.31 × 10-11 | 0.59 | 0 | ||||
rs17330779b | 7q31 | NRCAM (intron) | 0.10 | Allelic | 0.53 (0.41-0.69) | 0.53 (0.41-0.69) | 1.61 × 10-6 | 1.61 × 10-6 | 0.42 | 0 |
LAT | 0.50 (0.38-0.65) | 0.50 (0.38-0.65) | 5.96 × 10-7 | 5.96 × 10-7 | 0.38 | 0 | ||||
GOR | 0.49 (0.37-0.65) | 0.49 (0.37-0.65) | 4.72 × 10-7 | 4.72 × 10-7 | 0.42 | 0 | ||||
Domi | 0.49 (0.37-0.65) | 0.49 (0.37-0.65) | 5.01 × 10-7 | 5.01 × 10-7 | 0.44 | 0 | ||||
Rece | - | - | - | - | - | - | ||||
rs10824310b | 10q11.23 | PRKG1 (intron) | 0.06 | Allelic | 0.47 (0.35-0.64) | 0.47 (0.35-0.64) | 2.11 × 10-6 | 2.11 × 10-6 | 0.63 | 0 |
LAT | 0.45 (0.33-0.62) | 0.45 (0.33-0.62) | 1.41 × 10-6 | 1.41 × 10-6 | 0.56 | 0 | ||||
GOR | 0.44 (0.31-0.61) | 0.44 (0.31-0.61) | 7.37 × 10-7 | 7.37 × 10-7 | 0.67 | 0 | ||||
Domi | 0.43 (0.31-0.60) | 0.43 (0.31-0.60) | 7.04 × 10-7 | 7.04 × 10-7 | 0.68 | 0 | ||||
Rece | - | - | - | - | - | - | ||||
rs12162084 | 16 | Unknown | 0.16 | Allelic | 0.61 (0.50-0.75) | 0.61 (0.50-0.75) | 2.28 × 10-6 | 2.28 × 10-6 | 1.00 | 0 |
LAT | 0.59 (0.48-0.73) | 0.59 (0.48-0.73) | 1.56 × 10-6 | 1.56 × 10-6 | 0.99 | 0 | ||||
GOR | 0.56 (0.45-0.71) | 0.56 (0.45-0.71) | 9.50 × 10-7 | 9.50 × 10-7 | 0.94 | 0 | ||||
Domi | 0.56 (0.44-0.70) | 0.56 (0.44-0.70) | 1.15 × 10-6 | 1.15 × 10-6 | 0.84 | 0 | ||||
Rece | 0.55 (0.26-1.15) | 0.52 (0.17-1.60) | 1.13 × 10-1 | 2.55 × 10-1 | 0.22 | 34 | ||||
rs7077757 | 10q25.2 | RBM20 (intron) | 0.21 | Allelic | 0.64 (0.53-0.77) | 0.64 (0.53-0.77) | 2.45 × 10-6 | 2.45 × 10-6 | 0.92 | 0 |
LAT | 0.62 (0.51-0.76) | 0.62 (0.51-0.76) | 2.10 × 10-6 | 2.10 × 10-6 | 0.99 | 0 | ||||
GOR | 0.59 (0.47-0.73) | 0.59 (0.47-0.73) | 1.34 × 10-6 | 1.34 × 10-6 | 0.99 | 0 | ||||
Domi | 0.57 (0.46-0.72) | 0.57 (0.46-0.72) | 1.85 × 10-6 | 1.85 × 10-6 | 0.94 | 0 | ||||
Rece | 0.58 (0.34-1.00) | 0.57 (0.30-1.10) | 4.81 × 10-2 | 9.25 × 10-2 | 0.29 | 20 | ||||
rs10747758 | 12q14.2 | OR6U2P | 0.37 | Allelic | 0.69 (0.58-0.81) | 0.69 (0.58-0.81) | 3.97 × 10-6 | 3.97 × 10-6 | 0.50 | 0 |
LAT | 0.68 (0.57-0.80) | 0.68 (0.57-0.80) | 4.01 × 10-6 | 4.01 × 10-6 | 0.53 | 0 | ||||
GOR | 0.62 (0.51-0.76) | 0.62 (0.51-0.76) | 2.04 × 10-6 | 2.04 × 10-6 | 0.52 | 0 | ||||
Domi | 0.58 (0.46-0.73) | 0.58 (0.46-0.73) | 3.40 × 10-6 | 3.40 × 10-6 | 0.67 | 0 | ||||
Rece | 0.66 (0.48-0.90) | 0.66 (0.48-0.90) | 9.70 × 10-3 | 9.70 × 10-3 | 0.54 | 0 | ||||
rs2517509b | 6p21.33 | HCG22 | 0.03 | Allelic | 3.22 (1.94-5.34) | 3.22 (1.94-5.34) | 5.77 × 10-6 | 5.77 × 10-6 | 0.45 | 0 |
LAT | 3.27 (1.96-5.46) | 3.30 (1.93-5.63) | 5.85 × 10-6 | 1.27 × 10-5 | 0.35 | 4.7 | ||||
GOR | 3.31 (1.97-5.57) | 3.33 (1.95-5.70) | 6.58 × 10-6 | 1.14 × 10-5 | 0.36 | 3.3 | ||||
Domi | 3.31 (1.96-5.58) | 3.32 (1.94-5.69) | 7.53 × 10-6 | 1.19 × 10-5 | 0.36 | 2.8 | ||||
Rece | - | - | - | - | - | - | ||||