Table 1 A summary of the 5' regulatory elements and corresponding TFs found in the ATRX upstream regulatory region and 5'UTR

5'UTR of ATRX (+215 to +1)

YY1

(+38 to +29)

SNCCATNTT

CGCCATTTT

Activator/repressor involved in neural development with roles in the testis and meiosis

[35, 36]

ATRX promoter region

Inr element

(-2 to +3)

CTTNACC

CTTAACC

Binds to basal transcription factor TFIID

[19]

CCAAT boxes

(-2 to +3)

(-38 to -34)

(-69 to -65)

CCAAT

CCAAT

Binds NF-Y, C/EBP, GATA1, NF-E3

[42]

E2F

(-6 to -1)

TTTGGCGC

ATTGGCGC

Family of TFs that regulate mitosis, apoptosis, DNA repair, development and differentiation

[52]

CREB

(-122 to -117)

TGACGTCA

CGACGTCA

Mediation of basal and PKA-inducible transcription

[65]

HNF4

(-173 to -168)

TGACCT

TGACCT

Liver factor involved in liver development and digestive function

[66]

CR1

STAT5B

(-963 to -956)

TTCN₃GAA

TTCAAGAA

Involved in immune response, erythropoesis and mammary development

[67]

CP2

(-1017 to -1003)

A/TCTGG-

CNRGN₆CNRS

CTATT-

CCAGN₆GCAG

Regulates transcription of SRY. Initially shown to bind murine alpha-globin gene

[50]

E2F (-796 to -791)

TTTGGCGC

TTTGGCTG

See E2F above

[52]

CR2

HNF6

(-1413 to -1408)

GAATCA

GAAGCY

Liver factor involved in regulation of HNF4 and pancreatic precursor cells

[68]

CR3

FOXJ2/NKX2-5

(-12720 to -12714)

TNAAGTG

TTAAGTA

Involved in regulation of cardiogenesis

[69]