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Table 1 A summary of the 5' regulatory elements and corresponding TFs found in the ATRX upstream regulatory region and 5'UTR

From: Comparative analysis of the ATRX promoter and 5' regulatory region reveals conserved regulatory elements which are linked to roles in neurodevelopment, alpha-globin regulation and testicular function

  DNA binding consensus sequence Putative binding site found in putative ATRX promoter Biological roles References
5'UTR of ATRX (+215 to +1)
YY1
(+38 to +29)
SNCCATNTT CGCCATTTT Activator/repressor involved in neural development with roles in the testis and meiosis [35, 36]
ATRX promoter region
Inr element
(-2 to +3)
CTTNACC CTTAACC Binds to basal transcription factor TFIID [19]
CCAAT boxes
(-2 to +3)
(-38 to -34)
(-69 to -65)
CCAAT CCAAT Binds NF-Y, C/EBP, GATA1, NF-E3 [42]
E2F
(-6 to -1)
TTTGGCGC ATTGGCGC Family of TFs that regulate mitosis, apoptosis, DNA repair, development and differentiation [52]
CREB
(-122 to -117)
TGACGTCA CGACGTCA Mediation of basal and PKA-inducible transcription [65]
HNF4
(-173 to -168)
TGACCT TGACCT Liver factor involved in liver development and digestive function [66]
CR1
STAT5B
(-963 to -956)
TTCN3GAA TTCAAGAA Involved in immune response, erythropoesis and mammary development [67]
CP2
(-1017 to -1003)
A/TCTGG-
CNRGN6CNRS
CTATT-
CCAGN6GCAG
Regulates transcription of SRY. Initially shown to bind murine alpha-globin gene [50]
E2F (-796 to -791) TTTGGCGC TTTGGCTG See E2F above [52]
CR2
HNF6
(-1413 to -1408)
GAATCA GAAGCY Liver factor involved in regulation of HNF4 and pancreatic precursor cells [68]
CR3
FOXJ2/NKX2-5
(-12720 to -12714)
TNAAGTG TTAAGTA Involved in regulation of cardiogenesis [69]