Table 1 Criteria followed for evaluate signs and symptoms of adverse reactions

Indicated by medical personnel

Serum creatinine concentrations of 0.5 mg/dl or 50% increase over the baseline, whichever is the higher value¹⁴

Neutrophil count below 1,000 cells per cm³ of peripheral blood¹

Indicated by medical personnel after audiometric evaluations and reports of hearing loss after treatment, obtained by attending physicians in the process of anamnesis;

Platelet count less than 100,000 per microliter of peripheral blood

Indicated by attending physicians and reviewers, faced with the following standard of diagnosis: flushing, itching, chest pain, muscle spasm or hypotension during infusion of vancomycin