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Table 1 LC viability after treatment with immunomodulatory drugsa

From: Effects of immunomodulatory drugs on TNF-α and IL-12 production by purified epidermal langerhans cells and peritoneal macrophages

  Concentration Viability (%)
Freshly isolated LC - 94.4 ± 2.1
36 h cultured LC - 73.3 ± 2.8
Prednisone 10-6 M 69.9 ± 3.7
  10-8 M 66.7 ± 5.5
Thalidomide 10-6 M 63.5 ± 3.2
  10-8 M 61.4 ± 2.1
Cyclosporine A 10-6 M 62.2 ± 6.4
  10-8 M 61.2 ± 10.7
Amitriptyline 10-6 M 66.2 ± 2.2
  10-8 M 64.6 ± 1.7
  1. aPurified LC were cultured for 36 h in the presence or absence of 10-6 M or 10-8 M prednisone, thalidomide, cyclosporine A, or amitriptyline. Cell viability was then assessed using propidium iodide. All results are shown as mean ± SD for three independent experiments, which did not vary significantly from the control.