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Table 4 Functional annotation of genes associated with disease

From: Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1

Condition

Disease/Processes

Genes

Specific to Cyclin T2 depletion

Aging

Fas (TNF receptor superfamily, member 6)

  

N-acteyltransferase 1 (Arylamine N-acteyltransferase)

  

ATP-binding cassette, sub-family A (ABC1), member 1

  

Superoxide dismutase 2, mitochondrial

  

Hemochromatosis

Specific to Cyclin T1 depletion

HIV-1 biology

Cyclin dependent kinase 9 (Cdk9)

  

Cyclin T1

  

Granulin

  

Major histocompatibility complex, Class II, DM alpha

  

Tubulin, beta 6

 

Dementia

Amyloid beta (A4) precursor protein (peptidase Nexin-II, Alzheimer disease)

  

Very low density lipoprotein receptor

  

Estrogen receptor 1

  

Microtubule-associated protein (Tau)

  

Serpin peptidase inhibitor, clade 1 (Neuroserpin), member 1

  

Synuclein, alpha (non A4 component of amyloid precursor)

 

Cholesterol, LDL

Proprotein convertase Subtilisin/Kexin type 9

  

Low density lipoprotein receptor (familial hypercholesterolemia)

  

Apolipoprotein C-1

  

Low density lipoprotein receptor adaptor protein 1

 

Gallstones

Low density lipoprotein receptor-related protein associated Protein 1

  

Low density lipoprotein receptor (familial hypercholesterolemia)

  

Apolipoprotein C-1

 

Macular degeneration, age-related

very low density lipoprotein receptor

  

Microsomal Glutathione S-transferase 1

  

Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

 

Colorectal cancer

Platelet-derived growth factor receptor-like

  

V-HA-Ras Harvey rat sarcoma viral oncogene homolog

  

Mutated in colorectal cancers

 

Bladder cancer

V-HA-Ras Harvey rat sarcoma viral oncogene homolog

  

Fibroblast growth factor receptor 3 ( Achondroplasia, Thanatophoric dwarfism)

Common to Cyclin T2 and Cyclin T1 depletion

Metabolic

Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)

  

ATPase, class 1, Type 8B, member 1

  

Heme oxygenase (decycling) 1

  

Syndecan 2 (heparin sulfate proteoglycan 1, cell surface-associated, fibroglycan)

  

Bone morphogenetic protein 2

  

Calmodulin 1 (Phosphorylase kinase, delta)

  

Hydatidiform mole associated and imprinted

  

Scavenger receptor class B, member 1

  

Smad, mothers against DPP homolog 4 (Drosophila)

 

Metabolic

TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, psudoinflammatory)

  

Fibrillin 1 (Marfan syndrome

 

Cardiovascular

Neural precursor cell expressed, developmentally downregulated 4-like

  

Cyclin dependent kinase inhibitor 1C (p57, Kip2)

  

Caspase 1, Apoptosis-related Cysteine peptidase (Interleukin 1, beta, convertase)

  

Heme oxygenase (decycling) 1

  

Calmodulin 1 (Phosphorylase kinase, delta)

  

Poliovirus receptor-related 2 (Herpesvirus entry mediator B)

  

Scavenger receptor class B, member 1

  

TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, psudoinflammatory)

  1. The gene sets were investigated for potential link to diseases in a functional annotation analysis using DAVID. The disease states and the identity of genes potentially associated with it in the gene sets are presented.