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Table 4 Functional annotation of genes associated with disease

From: Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1

Condition Disease/Processes Genes
Specific to Cyclin T2 depletion Aging Fas (TNF receptor superfamily, member 6)
   N-acteyltransferase 1 (Arylamine N-acteyltransferase)
   ATP-binding cassette, sub-family A (ABC1), member 1
   Superoxide dismutase 2, mitochondrial
   Hemochromatosis
Specific to Cyclin T1 depletion HIV-1 biology Cyclin dependent kinase 9 (Cdk9)
   Cyclin T1
   Granulin
   Major histocompatibility complex, Class II, DM alpha
   Tubulin, beta 6
  Dementia Amyloid beta (A4) precursor protein (peptidase Nexin-II, Alzheimer disease)
   Very low density lipoprotein receptor
   Estrogen receptor 1
   Microtubule-associated protein (Tau)
   Serpin peptidase inhibitor, clade 1 (Neuroserpin), member 1
   Synuclein, alpha (non A4 component of amyloid precursor)
  Cholesterol, LDL Proprotein convertase Subtilisin/Kexin type 9
   Low density lipoprotein receptor (familial hypercholesterolemia)
   Apolipoprotein C-1
   Low density lipoprotein receptor adaptor protein 1
  Gallstones Low density lipoprotein receptor-related protein associated Protein 1
   Low density lipoprotein receptor (familial hypercholesterolemia)
   Apolipoprotein C-1
  Macular degeneration, age-related very low density lipoprotein receptor
   Microsomal Glutathione S-transferase 1
   Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
  Colorectal cancer Platelet-derived growth factor receptor-like
   V-HA-Ras Harvey rat sarcoma viral oncogene homolog
   Mutated in colorectal cancers
  Bladder cancer V-HA-Ras Harvey rat sarcoma viral oncogene homolog
   Fibroblast growth factor receptor 3 ( Achondroplasia, Thanatophoric dwarfism)
Common to Cyclin T2 and Cyclin T1 depletion Metabolic Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
   ATPase, class 1, Type 8B, member 1
   Heme oxygenase (decycling) 1
   Syndecan 2 (heparin sulfate proteoglycan 1, cell surface-associated, fibroglycan)
   Bone morphogenetic protein 2
   Calmodulin 1 (Phosphorylase kinase, delta)
   Hydatidiform mole associated and imprinted
   Scavenger receptor class B, member 1
   Smad, mothers against DPP homolog 4 (Drosophila)
  Metabolic TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, psudoinflammatory)
   Fibrillin 1 (Marfan syndrome
  Cardiovascular Neural precursor cell expressed, developmentally downregulated 4-like
   Cyclin dependent kinase inhibitor 1C (p57, Kip2)
   Caspase 1, Apoptosis-related Cysteine peptidase (Interleukin 1, beta, convertase)
   Heme oxygenase (decycling) 1
   Calmodulin 1 (Phosphorylase kinase, delta)
   Poliovirus receptor-related 2 (Herpesvirus entry mediator B)
   Scavenger receptor class B, member 1
   TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, psudoinflammatory)
  1. The gene sets were investigated for potential link to diseases in a functional annotation analysis using DAVID. The disease states and the identity of genes potentially associated with it in the gene sets are presented.