Figure 5

Obstruction of deltamethrin entry into CYP6P8 active site. (A) Predicted hydrogen bond formation between oxygen on ester of deltamethrin and guanidino group of R114. (B) Presence of R216 located across F123 in narrow active site channel. CYP6P8 is in rainbow mesh, ranging from blue (N-terminal) to red (C-terminal). Deltamethrin is represented by teal stick.