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Figure 1 | BMC Research Notes

Figure 1

From: Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk

Figure 1

Genes related with the tau protein phosphatase-2A (PP2A) pathway. PP2A dephosphorylates tau and is composed of an structural subunit A, a catalytic subunit alpha (PPP2CA) and a regulatory subunit B alpha (PPP2R2A). The peptidyl-prolyl cis/trans isomerase PIN1 binds to tau and facilitates PP2A activity, whereas ANP32A inhibits PP2A activity. Methylation by the leucine carboxyl methyltransferase-1 (LCMT1) increases PP2A activity, and demethylation by protein phosphatase methylesterase-1 (PPME1) reduces PP2A activity.

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BMC Research Notes

ISSN: 1756-0500

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