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Table 1 SCCD transepithelial and cellular currents

From: Sodium selectivity of semicircular canal duct epithelial cells

  

Na+-rich

K+-rich

  

control

amiloride

control

amiloride

permeable

Ussing chamber

(Isc, μA/cm2)

6.16 ± 0.83 (9)

1.00 ± 0.34 (9)*

1.71 ± 0.26 (12)

1.17 ± 0.3 (12) ns

 

Whole cell patch

(I-120 mV, pA/pF)

-60.8 ± 20.3 (9)

-36.3 ± 17.3 (9)*

-3.8 ± 0.1 (5)

-3.6 ± 0.3 (5) ns

impermeable

(I-120 mV, pA/pF)

Whole cell patch

-137.6 ± 68.7 (6)

-127.9 ± 64.2 (6) ns

-69.6 ± 6.1 (7)

-64.0 ± 5.7 (7)*

  1. Table entries are means ± SEM (number of experiments).
  2. Isc : short circuit current (μA/cm2), I-120 mV : whole-cell patch clamp current at -120 mV command voltage (pA/pF)
  3. Amilorde concentration was 100 μM for all experiments.
  4. Significant differences: *, P < 0.05; ns, not significant.
  5. Comparisons: Values in amiloride vs control (without amiloride) using the paired t-test.