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Table 2 Amiloride sensitive channels

From: Sodium selectivity of semicircular canal duct epithelial cells

name gene bank gene amiloride, IC50, μM cation selectivity, PNa/PK gene array*, DEX (GEO, GSE6197) reference
α-ENaC NM_031548 Scnn1a 0.17 1 P [15, 14, 20, 21]
αβ-ENaC U35174 Scnn1b 4 ≥ 100 P [18, 19]
αγ-ENaC U37539 Scnn1g 0.13 ≥ 100 P [18, 19]
αβγ-ENaC    0.1 ≥ 100 P [16, 18, 14]
ASIC2a Y14635 Accn1 28 ≥ 10 A [18, 31]
ASIC1a NM_024154 Accn2 10 6-13 P [18, 31, 32]
CNGA1 NM_012923 Ccng1 (100 tested)** 1 P [2325, 27]
CNGA2 AF_126808 Cncg4 ND 1 A [24, 25, 27, 26]
CNGA3 AJ272429 Cnga3 ND 1 A [24, 25, 27, 26]
HCN1 NM_053375 Hcn1 ND 0.3 P [28, 29, 35]
HCN2 AI112487, AW532988 Hcn2 ND 0.3 A [28, 29, 35]
HCN3 NM_053685 Hcn3 ND 0.3 P [28, 29, 35]
HCN4 AF247453 Hcn4 ND 0.3 A [28, 29, 35]
TRPV1 AB015231, AF158248, AB041029 Trpv1 Insens NSC A [36, 37]
TRPV2 NM_017207 Vrl1 ND NSC A [36]
TRPV4 NM_023970 Trpv4 ND NSC A [36]
TRPV6 NM_053686 Trpv6 ND NSC A [36]
  1. * gene was detected as present (P) or absent (A) in the presence of 100 nM dexamethasone.
  2. ** CNGA1 channels were not inhibited by 100 μM amiloride.
  3. Insens, insensitive; ND, not determined; NSC, non-selective cation channels.