Sodium selectivity of semicircular canal duct epithelial cells

BMC Research Notes

Table 2 Amiloride sensitive channels

name	gene bank	gene	amiloride, IC₅₀, μM	cation selectivity, P_Na/P_K	gene array*, DEX (GEO, GSE6197)	reference
α-ENaC	NM_031548	Scnn1a	0.17	1	P	[15, 14, 20, 21]
αβ-ENaC	U35174	Scnn1b	4	≥ 100	P	[18, 19]
αγ-ENaC	U37539	Scnn1g	0.13	≥ 100	P	[18, 19]
αβγ-ENaC			0.1	≥ 100	P	[16, 18, 14]
ASIC2a	Y14635	Accn1	28	≥ 10	A	[18, 31]
ASIC1a	NM_024154	Accn2	10	6-13	P	[18, 31, 32]
CNGA1	NM_012923	Ccng1	(100 tested)**	1	P	[23–25, 27]
CNGA2	AF_126808	Cncg4	ND	1	A	[24, 25, 27, 26]
CNGA3	AJ272429	Cnga3	ND	1	A	[24, 25, 27, 26]
HCN1	NM_053375	Hcn1	ND	0.3	P	[28, 29, 35]
HCN2	AI112487, AW532988	Hcn2	ND	0.3	A	[28, 29, 35]
HCN3	NM_053685	Hcn3	ND	0.3	P	[28, 29, 35]
HCN4	AF247453	Hcn4	ND	0.3	A	[28, 29, 35]
TRPV1	AB015231, AF158248, AB041029	Trpv1	Insens	NSC	A	[36, 37]
TRPV2	NM_017207	Vrl1	ND	NSC	A	[36]
TRPV4	NM_023970	Trpv4	ND	NSC	A	[36]
TRPV6	NM_053686	Trpv6	ND	NSC	A	[36]

* gene was detected as present (P) or absent (A) in the presence of 100 nM dexamethasone.
** CNGA1 channels were not inhibited by 100 μM amiloride.
Insens, insensitive; ND, not determined; NSC, non-selective cation channels.

ISSN: 1756-0500