Figure 2

HF can be modified into functional and non-functional analogs. (A) Structures of MAZ1319 and (B) MAZ1310. (C) HF and MAZ1319 but not MAZ1310 induce transcription of Smad7 (C) in NMuMG cells after 8 hours of treatment. All samples were normalized to β-Actin transcript levels. The fold induction of Smad7 is calculated relative to DMSO vehicle treatment)