TY - JOUR AU - Uhl, Michael AU - Mellert, Kevin AU - Striegl, Britta AU - Deibler, Martin AU - Lamla, Markus AU - Spatz, Joachim P. AU - Kemkemer, Ralf AU - Kaufmann, Dieter PY - 2011 DA - 2011/10/31 TI - Cyclic stretch increases splicing noise rate in cultured human fibroblasts JO - BMC Research Notes SP - 470 VL - 4 IS - 1 AB - Mechanical forces are known to alter the expression of genes, but it has so far not been reported whether they may influence the fidelity of nucleus-based processes. One experimental approach permitting to address this question is the application of cyclic stretch to cultured human fibroblasts. As a marker for the precision of nucleus-based processes, the number of errors that occur during co-transcriptional splicing can then be measured. This so-called splicing noise is found at low frequency in pre-mRNA splicing. SN - 1756-0500 UR - https://doi.org/10.1186/1756-0500-4-470 DO - 10.1186/1756-0500-4-470 ID - Uhl2011 ER -