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Table 2 In vitro antiplasmodial activity (IC50) of Fabaceae extracts on field isolates of P. falciparum

From: In vitro antiplasmodial activity of crude extracts of Tetrapleura tetraptera and Copaifera religiosa

 

IC50 ± SD (μg/mL)

IC50 ± SD (nM)

Isolates

Tetrapleura tetraptera (μg/ml)

Copaifera religiosa (μg/ml)

DHA (nM)

CQ (nM)

 

CH2Cl2

MeOH

CH2Cl2

MeOH

  

21431

0.6 ± 0.7

11.0 ± 0.6

1.1 ± 0.4

200 ± 10.6

0.3 ± 0.1

3.4 ± 2.0

21439

0.5 ± 0.2

12.6 ± 0.9

0.9 ± 0.5

75 ± 4.8

0.6 ± 0.2

110.0 ± 7.3

21489

0.8 ± 0.3

10.2 ± 2.3

1.6 ± 0.8

20 ± 3.5

4.8 ± 1.0

107.7 ± 2.1

21542

1.2 ± 0.5

14.7 ± 1.5

3.6 1.3

25.6 ± 2.1

5.8 ± 0.8

143.0 ± 2.3

21552

5.0 ± 1.1

75.4 ± 8.6

30.3 ± 1.3

400 ± 23.4

0.9 ± 0.2

100.0 ± 9.3

21657

0.9 ± 0.4

23.8 ± 9.4

9.1 ± 1.6

236 ± 9.7

2.0 ± 0.5

3.6 ± 0.8

21660

1.2 ± 0.2

13.5 ± 7.8

0.9 ± 0.3

88 ± 10.2

0.6 ± 0.3

212.8 ± 3.9

21676

1.0 ± 0.5

9.3 ± 0.9

2.4 ± 1.7

45.2 ± 1.8

5.9 ± 1.8

183.8 ± 12.8

21679

2.1 ± 0.5

11.2 ± 2.6

1.1 ± 0.3

320.7 ± 9.3

6.4 ± 1.1

278.5 ± 5.4

21681

0.7 ± 0.6

12.5 ± 3.4

0.9 ± 0.6

264.6 ± 8.4

11.1 ± 1.7

29.5 ± 10.4

21683

1.7 ± 0.4

13.8 ± 1.4

1.5 ± 0.2

321.3 ± 3.1

1.0 ± 0.4

70.6 ± 2.6

21700

2.6 ± 1.0

14.9 ± 0.7

2.7 ± 0.6

200.1 ± 6.0

1.9 ± 0.4

7.8 ± 2.1

21706

0.8 ± 0.3

11.7 ± 1.6

3.6 ± 1.5

697.6 ± 8.2

1.0 ± 0.3

375.2 ± 4.3

21721

0.7 ± 0.3

9.9 ± 0.8

1.3 ± 0.5

345.7 ± 13.6

0.1 ± 0.2

60.0 ± 2.3

21743

1.8 ± 1.4

14.2 ± 3.7

2.6 ± 0.6

294.3 ± 7.3

0.6 ± 0.2

17.9 ± 1.8

21782

0.7 ± 0.3

15.9 ± 0.9

0.8 ± 0.6

219.6 ± 20.3

2.1 ± 0.6

26.6 ± 2.1

Median (Min-Max)*

0.9 (0.5-5.0)

13.1 (9.3-75.4)

1.5 (0.8-30.8)

227.8 (20.0-697.6)

1.45 (0.1-11.1)

85.3 (3.4-375.2)

  1. Median (Min-Max)*: median of IC50 with minimum and maximum.
  2. DHA: dihydroartemisinin.
  3. CQ: chloroquine.