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Table 2 In vitro antiplasmodial activity (IC50) of Fabaceae extracts on field isolates of P. falciparum

From: In vitro antiplasmodial activity of crude extracts of Tetrapleura tetraptera and Copaifera religiosa

  IC50 ± SD (μg/mL) IC50 ± SD (nM)
Isolates Tetrapleura tetraptera (μg/ml) Copaifera religiosa (μg/ml) DHA (nM) CQ (nM)
  CH2Cl2 MeOH CH2Cl2 MeOH   
21431 0.6 ± 0.7 11.0 ± 0.6 1.1 ± 0.4 200 ± 10.6 0.3 ± 0.1 3.4 ± 2.0
21439 0.5 ± 0.2 12.6 ± 0.9 0.9 ± 0.5 75 ± 4.8 0.6 ± 0.2 110.0 ± 7.3
21489 0.8 ± 0.3 10.2 ± 2.3 1.6 ± 0.8 20 ± 3.5 4.8 ± 1.0 107.7 ± 2.1
21542 1.2 ± 0.5 14.7 ± 1.5 3.6 1.3 25.6 ± 2.1 5.8 ± 0.8 143.0 ± 2.3
21552 5.0 ± 1.1 75.4 ± 8.6 30.3 ± 1.3 400 ± 23.4 0.9 ± 0.2 100.0 ± 9.3
21657 0.9 ± 0.4 23.8 ± 9.4 9.1 ± 1.6 236 ± 9.7 2.0 ± 0.5 3.6 ± 0.8
21660 1.2 ± 0.2 13.5 ± 7.8 0.9 ± 0.3 88 ± 10.2 0.6 ± 0.3 212.8 ± 3.9
21676 1.0 ± 0.5 9.3 ± 0.9 2.4 ± 1.7 45.2 ± 1.8 5.9 ± 1.8 183.8 ± 12.8
21679 2.1 ± 0.5 11.2 ± 2.6 1.1 ± 0.3 320.7 ± 9.3 6.4 ± 1.1 278.5 ± 5.4
21681 0.7 ± 0.6 12.5 ± 3.4 0.9 ± 0.6 264.6 ± 8.4 11.1 ± 1.7 29.5 ± 10.4
21683 1.7 ± 0.4 13.8 ± 1.4 1.5 ± 0.2 321.3 ± 3.1 1.0 ± 0.4 70.6 ± 2.6
21700 2.6 ± 1.0 14.9 ± 0.7 2.7 ± 0.6 200.1 ± 6.0 1.9 ± 0.4 7.8 ± 2.1
21706 0.8 ± 0.3 11.7 ± 1.6 3.6 ± 1.5 697.6 ± 8.2 1.0 ± 0.3 375.2 ± 4.3
21721 0.7 ± 0.3 9.9 ± 0.8 1.3 ± 0.5 345.7 ± 13.6 0.1 ± 0.2 60.0 ± 2.3
21743 1.8 ± 1.4 14.2 ± 3.7 2.6 ± 0.6 294.3 ± 7.3 0.6 ± 0.2 17.9 ± 1.8
21782 0.7 ± 0.3 15.9 ± 0.9 0.8 ± 0.6 219.6 ± 20.3 2.1 ± 0.6 26.6 ± 2.1
Median (Min-Max)* 0.9 (0.5-5.0) 13.1 (9.3-75.4) 1.5 (0.8-30.8) 227.8 (20.0-697.6) 1.45 (0.1-11.1) 85.3 (3.4-375.2)
  1. Median (Min-Max)*: median of IC50 with minimum and maximum.
  2. DHA: dihydroartemisinin.
  3. CQ: chloroquine.