From: In vitro antiplasmodial activity of crude extracts of Tetrapleura tetraptera and Copaifera religiosa
 | IC50 ± SD (μg/mL) | IC50 ± SD (nM) | ||||
---|---|---|---|---|---|---|
Isolates | Tetrapleura tetraptera (μg/ml) | Copaifera religiosa (μg/ml) | DHA (nM) | CQ (nM) | ||
 | CH2Cl2 | MeOH | CH2Cl2 | MeOH |  |  |
21431 | 0.6 ± 0.7 | 11.0 ± 0.6 | 1.1 ± 0.4 | 200 ± 10.6 | 0.3 ± 0.1 | 3.4 ± 2.0 |
21439 | 0.5 ± 0.2 | 12.6 ± 0.9 | 0.9 ± 0.5 | 75 ± 4.8 | 0.6 ± 0.2 | 110.0 ± 7.3 |
21489 | 0.8 ± 0.3 | 10.2 ± 2.3 | 1.6 ± 0.8 | 20 ± 3.5 | 4.8 ± 1.0 | 107.7 ± 2.1 |
21542 | 1.2 ± 0.5 | 14.7 ± 1.5 | 3.6 1.3 | 25.6 ± 2.1 | 5.8 ± 0.8 | 143.0 ± 2.3 |
21552 | 5.0 ± 1.1 | 75.4 ± 8.6 | 30.3 ± 1.3 | 400 ± 23.4 | 0.9 ± 0.2 | 100.0 ± 9.3 |
21657 | 0.9 ± 0.4 | 23.8 ± 9.4 | 9.1 ± 1.6 | 236 ± 9.7 | 2.0 ± 0.5 | 3.6 ± 0.8 |
21660 | 1.2 ± 0.2 | 13.5 ± 7.8 | 0.9 ± 0.3 | 88 ± 10.2 | 0.6 ± 0.3 | 212.8 ± 3.9 |
21676 | 1.0 ± 0.5 | 9.3 ± 0.9 | 2.4 ± 1.7 | 45.2 ± 1.8 | 5.9 ± 1.8 | 183.8 ± 12.8 |
21679 | 2.1 ± 0.5 | 11.2 ± 2.6 | 1.1 ± 0.3 | 320.7 ± 9.3 | 6.4 ± 1.1 | 278.5 ± 5.4 |
21681 | 0.7 ± 0.6 | 12.5 ± 3.4 | 0.9 ± 0.6 | 264.6 ± 8.4 | 11.1 ± 1.7 | 29.5 ± 10.4 |
21683 | 1.7 ± 0.4 | 13.8 ± 1.4 | 1.5 ± 0.2 | 321.3 ± 3.1 | 1.0 ± 0.4 | 70.6 ± 2.6 |
21700 | 2.6 ± 1.0 | 14.9 ± 0.7 | 2.7 ± 0.6 | 200.1 ± 6.0 | 1.9 ± 0.4 | 7.8 ± 2.1 |
21706 | 0.8 ± 0.3 | 11.7 ± 1.6 | 3.6 ± 1.5 | 697.6 ± 8.2 | 1.0 ± 0.3 | 375.2 ± 4.3 |
21721 | 0.7 ± 0.3 | 9.9 ± 0.8 | 1.3 ± 0.5 | 345.7 ± 13.6 | 0.1 ± 0.2 | 60.0 ± 2.3 |
21743 | 1.8 ± 1.4 | 14.2 ± 3.7 | 2.6 ± 0.6 | 294.3 ± 7.3 | 0.6 ± 0.2 | 17.9 ± 1.8 |
21782 | 0.7 ± 0.3 | 15.9 ± 0.9 | 0.8 ± 0.6 | 219.6 ± 20.3 | 2.1 ± 0.6 | 26.6 ± 2.1 |
Median (Min-Max)* | 0.9 (0.5-5.0) | 13.1 (9.3-75.4) | 1.5 (0.8-30.8) | 227.8 (20.0-697.6) | 1.45 (0.1-11.1) | 85.3 (3.4-375.2) |