Comparison of the reference and filtered networks' disconnectivity. A vertex' value indicates the portion of all connected pairs of vertices in the network that become disconnected after its removal. For better comparison, the values are normalized to fill the interval [0, 1]. (A) The scaled Dis in the breast cancer data strictly filtered network is plotted against the scaled Dis in the underlying reference network. EGF pathway-related kinases increase while p53 drastically decrease. (B) In the corresponding 1-extended network, a large cluster of nodes has small Dis before and after filtering, only p53 remains at the highest level.