Table 2 Summary of the disconnectivity key node analysis.
From: Integration of gene expression data with prior knowledge for network analysis and validation
Network | Method | 1st Key node | 2nd Key node | 3rd Key node | 4th Key node | 5th Key node |
|---|---|---|---|---|---|---|
Signaling Network | strict | MEK1 (0.21) | SHP-2 (0.20) | Abl (0.18) | ERK1 (0.14) | MEKK1 (0.13) |
| Â | 1-ext. | p53 (0.16) | SHIP (0.06) | PIAS1 (0.06) | Fyn (0.06) | PAK2 (0.04) |
Metabolic Network | strict | Nucleoside-diphosphate kinase (0.39) | Hexokinase (0.32) | Phosphatidate phosphatase (0.26) | Glucosyl-ceramidase (0.25) | Glucosyl-ceramide synthase (0.24) |
| Â | 1-ext. | Lipoprotein lipase (0.22) | Nucleoside-diphosphate kinase (0.14) | Succinate-CoA ligase (GDP-forming) (0.14) | 5'-nucleotidase (0.12) | Hexokinase (0.11) |