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Table 1 Summary of the ryr genes identified in zebrafish and their identity to the human orthologues.

From: Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development

Genes cDNA length (bp) Numbers of Exons Genome Location Coding Region (aa) Identity to Human isoforms#
ryr1a 15,195 108 Chromosome 10: 29.76 m 5,064 76%
ryr1b 15,231 100* Chromosome 18: 36.78 m 5,076 76%
ryr2a N/A N/A 5 contigs so far; scaffolds 2,829 86%
ryr2b 14,748 121* Chromosome 17: 18.70 m 4,916 63%
ryr3 15,122 98 Chromosome 20: 38.11 m 4,863 77%
  1. The zebrafish ryr1a, ryr1b, ryr2b and ryr3 genes are composed of 108, 100, 121 and 98 exons, and encode proteins of 5064, 5076, 4916 and 4870 amino acids (aa), respectively (Data from Zv7 Ensembl and BLAT Search). To date, five genomic contigs were identified for ryr2a, which spans 2829 amino acids, based on a protein tBLASTn searching approach using human RyR2 peptide
  2. * = BLAT RESULTS and # = ClustalW Alignment Score