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Table 1 Summary of the ryr genes identified in zebrafish and their identity to the human orthologues.

From: Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development

Genes

cDNA length (bp)

Numbers of Exons

Genome Location

Coding Region (aa)

Identity to Human isoforms#

ryr1a

15,195

108

Chromosome 10: 29.76 m

5,064

76%

ryr1b

15,231

100*

Chromosome 18: 36.78 m

5,076

76%

ryr2a

N/A

N/A

5 contigs so far; scaffolds

2,829

86%

ryr2b

14,748

121*

Chromosome 17: 18.70 m

4,916

63%

ryr3

15,122

98

Chromosome 20: 38.11 m

4,863

77%

  1. The zebrafish ryr1a, ryr1b, ryr2b and ryr3 genes are composed of 108, 100, 121 and 98 exons, and encode proteins of 5064, 5076, 4916 and 4870 amino acids (aa), respectively (Data from Zv7 Ensembl and BLAT Search). To date, five genomic contigs were identified for ryr2a, which spans 2829 amino acids, based on a protein tBLASTn searching approach using human RyR2 peptide
  2. * = BLAT RESULTS and # = ClustalW Alignment Score