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Figure 1 | BMC Research Notes

Figure 1

From: Idebenone increases mitochondrial complex I activity in fibroblasts from LHON patients while producing contradictory effects on respiration

Figure 1

The effect of idebenone on complex I activity. A. Complex I (CxI) activity in fibroblasts from LHON patients (n = 9) and controls (n = 3) treated with vehicle (grey bars) or 10 μM idebenone (black bars) 24 h before the analysis. The enzymatic activity was standardized in terms of citrate synthase (CS) activity, indicative of mitochondrial mass and expressed as the percentage of activity of one control fibroblast used as reference in all experiments (CxI/CS(%)). B. Pooled results from fibroblasts from LHON patients and controls. Results are expressed as mean values ± SD. Statistical significance: **p < 0.01 compared with vehicle-treated fibroblasts from LHON patients. C = Controls and P = Patients.

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BMC Research Notes

ISSN: 1756-0500

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