Skip to main content
Figure 2 | BMC Research Notes

Figure 2

From: Idebenone increases mitochondrial complex I activity in fibroblasts from LHON patients while producing contradictory effects on respiration

Figure 2

The effect of idebenone on complex I-driven respiration. Determination of complex I-driven respiration in permeabilized fibroblasts from LHON patients (n = 6) and controls (n = 3) treated with vehicle (grey bars) or 10 μM idebenone (black bars). The I/(I+II) ratio corresponds to the fraction of respiration driven by complex I with respect to the maximal respiratory rate driven by complexes I and II. A. Pooled results of fibroblasts from Patients 1-6 and controls. B. Individual results of Patients 1-6 and controls. C. Pooled results of fibroblasts from Patients 1, 3 and 6, in which idebenone impaired respiration, and Patients 2, 4 and 5, in which idebenone stimulated respiration. Results are expressed as mean values ± SD. Statistical significance: *p < 0.05 compared with vehicle-treated fibroblasts from LHON patients. C = Controls and P = Patients.

Back to article page

BMC Research Notes

ISSN: 1756-0500

Contact us