Table 1 Amino acids reported by ICM PocketFinder to contribute to the binding pockets of open-to-out DAT, NET and SERT
From: A short update on the structure of drug binding sites on neurotransmitter transporters
DAT | NET | SERT | |
|---|---|---|---|
TMH1 | F76, A77, D79, L80 A81, W84, R85, Y88 | F72, A73, D75, L76, A77, W80, R81, Y84 | Y95, A96, D98, G100, W103, R104, Y107, I108 |
TMH3 | V152, F155, Y156, I159 | 145, V148, Y151, Y152, I155, W158 | A169, I172, A173, Y175, Y176, I179, W182 |
TMH6 | F320, S321, G323, F326, V328 | F317, S318, G320, F323, V325 | F335, L336, L337, G338, F341, V343 |
EL4 | V382, A383, K384, D385, G386, P387, L389, I390 | A380, E382, G383, A384, L386, V387, F388 | A398, K399, D400, A401, P403, L405, L406, F407 |
TMH8 | S422, A423, G426 | S419, S420, G423 | S438, T439, G442 |
TMH10 | F472, D476, A480 | G465, I466, L469, T470 | E493, T497 |