Figure 1

Amino acid sequence alignment generated from samples at baseline and at most recent time points covering amino acids 161 - 236 of the HBV reverse transcriptase domain. The HBV RT sequences are aligned with reference genotype E sequence (X75664) which is shown at the top, alignment with patient sequence is shown below with identities marked as (.) and sequence changes indicated by letter. Sequences from patients who developed YMDD mutations (patients 6, 12 and 13) during 3TC therapy are shown at the top half of the figure. The baseline and post treatment time points are represented by '01' and '02' respectively.