TY - JOUR AU - Nava-Salazar, Sonia AU - Sánchez-Rodríguez, Elly N. AU - Mendoza-Rodríguez, C. Adriana AU - Moran, Carlos AU - Romero-Arauz, Juan F. AU - Cerbón, Marco A. PY - 2011 DA - 2011/03/17 TI - Polymorphisms in the hypoxia-inducible factor 1 alpha gene in Mexican patients with preeclampsia: A case-control study JO - BMC Research Notes SP - 68 VL - 4 IS - 1 AB - Although the etiology of preeclampsia is still unclear, recent work suggests that changes in circulating angiogenic factors play a key role in its pathogenesis. In the trophoblast of women with preeclampsia, hypoxia-inducible factor 1 alpha (HIF-1α) is over-expressed, and induces the expression of non-angiogenic factors and inhibitors of trophoblast differentiation. This observation prompted the study of HIF-1α and its relation to preeclampsia. It has been described that the C1772T (P582S) and G1790A (A588T) polymorphisms of the HIF1A gene have significantly greater transcriptional activity, correlated with an increased expression of their proteins, than the wild-type sequence. In this work, we studied whether either or both HIF1A variants contribute to preeclampsia susceptibility. SN - 1756-0500 UR - https://doi.org/10.1186/1756-0500-4-68 DO - 10.1186/1756-0500-4-68 ID - Nava-Salazar2011 ER -