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Table 4 Nuclear FGFR2 Staining in Breast Tumours compared to Normal Tissue

From: FGFR2 protein expression in breast cancer: nuclear localisation and correlation with patient genotype

 

Nuclear Score

0

Nuclear Score

>0

Nuclear Score

0-3

Nuclear Score

4+

Normal Tissue

15

14

28

1

Tumour

(normal present)

11

18

22

7

 

p = 0.43 (Fishers Exact Test)

p = 0.05 (Fishers Exact Test)

Tumour (All)

12

28

27

13

 

p = 0.12 (Fishers Exact Test)

p = 0.005* (Fishers Exact Test)

  1. A comparison of FGFR2 staining in normal tissue and tumour tissue. The analysis is performed twice, firstly for a cut-off of 0 (no staining), and secondly for staining scores of 4 or greater. Initially the analysis was performed using data from the 29 cases where both tumour and normal tissue were present in the same slide. Subsequently, we also repeated the analysis using data from all 40 tumours compared to the 29 normal tissues that could be scored. When using a cut-off of 4, the first analysis showed marginal significance using a Fishers exact test, with a higher level of significance seen if all the data was included. This suggests increased FGFR2 staining in a proportion of tumours compared to normal tissue.