KIAA0191 and E2F1 expression can be combined to accurately group patients into low, medium and high risk groups. A) Tree-based decision strategy to integrate KIAA0191 expression into our model of using E2F1 expression to separate breast cancer patients into good and poor prognosis groups. B) % survival over time for low, medium and high risk patients. Patients with low E2F1 expression group directly into the low risk group, however, when patients had either high or average E2F1 expression we also used KIAA0191 expression to classify these patients among the various risk groups. Patients with average E2F1 expression and either low or high KIAA0191 expression where grouped into low and medium risk groups, respectively, whereas patients with high E2F1 expression and either low or high KIAA0191 expression were grouped into medium and high risk groups. C) Patients who survived or succumbed to breast cancer for each risk group, as well as associated hazard ratios between risk groups.