binding site | position [bp]‡ | core similarity§ | matrix- similarity$ | sequence |
|---|
| | start | end | | | capitals: core sequence† |
|---|
a
| -471 | -457 | 1,0 | 0,942 | gtgGGGCggcgcatg |
b
| -303 | -289 | 1,0 | 0,930 | gcaGGGCgggaggag |
c
| -224 | -210 | 1,0 | 0,956 | gggGGGCggaggctg |
d
| -102 | -88 | 0,772 | 0,883 | gcgAGGCggggactc |
- ‡Numbering of the position is relative to the egfr translational start codon (ATG)
- §The maximum core similarity of 1.0 is only reached when the highest conserved bases of a matrix match exactly in the sequence [14, 15]
- $A perfect match to the matrix gets a score of 1.00 (each sequence position corresponds to the highest conserved nucleotide at that position in the matrix), a "good" match to the matrix usually has a similarity of > 0.80 [14, 15]
- †The "core sequence" of a matrix is defined as the (usually 4-5) highest conserved positions of the matrix [14, 15]
