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Table 3 Results of the per protocol analysis after 2 years of follow-up.

From: Randomised clinical trial of an intensive intervention in the primary care setting of patients with high plasma fibrinogen in the primary prevention of cardiovascular disease

Outcome measure Intensive intervention (n = 154) mean ± SD Standard intervention (n = 146) mean ± SD Adjusted difference mean* 95% CI p value
Fibrinogen§ 306.3 ± 57.9 337.6 ± 68.8 31.0 17.0-45.0 0.0001
Total cholesterol 204.4 ± 30.5 224.4 ± 32.0 19.2 12.7-25.6 0.0001
cHDL 61.7 ± 15.1 60.3 ± 14.6 2.1 -0.9 to 51 0.171
cLDL 131.1 ± 28.0 129.6 ± 31.4 -19 -9.9 to 6.0 0.633
Triglycerides 115.1 ± 56.5 119.2 ± 55.4 5.6 -7.4 to 18.6 0.394
SBP 129.6 ± 15.1 136.9 ± 14.8 6.8 2.8-10.7 0.0001
DBP 75.5 ± 9.7 80.4 ± 8.7 4.4 2.0-6.8 0.0001
BMI 29.6 ± 4.8 31.8 ± 4.9 1.7 1.1-2.2 0.0001
HbA1C (diabetic patients) 7.2 ± 1.7 7.7 ± 1.3 0.5 -0.5 to 1.6 0.340
  1. depending on the type of intervention. All comparisons of outcome scores between interventions groups are presented as the difference in means after adjusting for baseline outcome measures
  2. * Difference between groups using covariance analysis after adjusting for baseline outcome measure. Positive values favour intensive intervention
  3. § is an independent variable
  4. SD standard deviation; CI confidence interval; cHDL high density cholesterol lipoprotein; cLDL low density lipoprotein cholesterol; SBP systolic blood pressure;
  5. DBP diastolic blood pressure; BMI body mass index; HbA1C glycated haemoglobin