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Table 3 Results of the per protocol analysis after 2 years of follow-up.

From: Randomised clinical trial of an intensive intervention in the primary care setting of patients with high plasma fibrinogen in the primary prevention of cardiovascular disease

Outcome

measure

Intensive

intervention

(n = 154) mean ±

SD

Standard

intervention

(n = 146) mean ±

SD

Adjusted

difference

mean*

95% CI

p value

Fibrinogen§

306.3 ± 57.9

337.6 ± 68.8

31.0

17.0-45.0

0.0001

Total cholesterol

204.4 ± 30.5

224.4 ± 32.0

19.2

12.7-25.6

0.0001

cHDL

61.7 ± 15.1

60.3 ± 14.6

2.1

-0.9 to 51

0.171

cLDL

131.1 ± 28.0

129.6 ± 31.4

-19

-9.9 to 6.0

0.633

Triglycerides

115.1 ± 56.5

119.2 ± 55.4

5.6

-7.4 to 18.6

0.394

SBP

129.6 ± 15.1

136.9 ± 14.8

6.8

2.8-10.7

0.0001

DBP

75.5 ± 9.7

80.4 ± 8.7

4.4

2.0-6.8

0.0001

BMI

29.6 ± 4.8

31.8 ± 4.9

1.7

1.1-2.2

0.0001

HbA1C (diabetic patients)

7.2 ± 1.7

7.7 ± 1.3

0.5

-0.5 to 1.6

0.340

  1. depending on the type of intervention. All comparisons of outcome scores between interventions groups are presented as the difference in means after adjusting for baseline outcome measures
  2. * Difference between groups using covariance analysis after adjusting for baseline outcome measure. Positive values favour intensive intervention
  3. § is an independent variable
  4. SD standard deviation; CI confidence interval; cHDL high density cholesterol lipoprotein; cLDL low density lipoprotein cholesterol; SBP systolic blood pressure;
  5. DBP diastolic blood pressure; BMI body mass index; HbA1C glycated haemoglobin